Antipsychotics for dementia linked to more harms than previously acknowledged
Antipsychotic use in people with dementia is associated with higher risks of a wide range of serious health outcomes compared with non-use, according to a new study from a collaboration across the Universities of Manchester, Nottingham, Edinburgh and Dundee.
Higher rates of stroke, blood clots, heart attack, heart failure, fracture, pneumonia, and acute kidney injury were observed in the study funded by the National Institute for Health and Care Research (NIHR)and published in The BMJ (17/04/24)
The findings show a considerably wider range of harms associated with antipsychotic use in people with dementia than previously acknowledged in regulatory alerts, with risks highest soon after starting the drugs, underscoring the need for increased caution in the early stages of treatment.
Despite safety concerns, antipsychotics continue to be widely prescribed for behavioural and psychological symptoms of dementia such as apathy, depression, aggression, anxiety, irritability, delirium, and psychosis.
Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study | The BMJ
antipsychotics.pdf (psprings.co.uk)
Healthcare Quality and Patient Safety
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